Optic Nerve Meeting 2024
10-12 December
AGENDA
DOWNLOAD
20 minute slot = 10 minute talk and 10 minute discussion | ||
10 minute slot = 5 minute talk and 5 minute discussion | ||
Tuesday 10th December | ||
8:30 - 8:40 | Jonathan, Keith & Franz | Welcome and Introduction |
Session 1: Glia | ||
Chairs: Keith Martin, Franz Grus | ||
8:40 - 9:00 | Tom Reh | Müller glia can be reprogrammed to make retinal ganglion cells; now what? |
9:00 - 9:20 | Michel Cayouette | Retinal glia regulate the development and function of ipRGCs |
9:20 - 9:40 | Tatjana Jakob | Alpha retinal ganglion cell to microglia signaling in glaucoma |
9:40 -10:00 | Thora Karadottir | Oligodendrocytes and ageing |
Morning Tea | ||
Session 2: Autophagy and mitochondria | ||
Chairs: Christian Behl, Pete Williams | ||
10:30 - 10:50 | Hagen Körschgen | Unraveling BAG3-mediated aggrephagy - implications for neurodegeneration |
10:50 - 11:10 | Marcella Votruba | NAM as a neuroprotective therapeutic intervention for mitochondrial optic neuropathies |
11:10 - 11:30 | Elena Vecino | Implications of mitochondria in the neuroprotection and neuroregeneration of RGCs |
11:30 - 11:50 | Katharina Bell | Effect of age on the senescence transcriptome in mouse and human retina |
11:50 - 12:00 | Xandra Pereiro | TRPV4 modulation in Müller glia: Impact on gliosis and retinal cell survival |
Lunch Break | ||
Session 3: Transient IOP fluctuations - do they matter? | ||
Chairs: Crawford Downs, Claire Mitchell | ||
17:30 - 17:50 | Crawford Downs | Intraocular and cerebrospinal pressure fluctuations: Biomechanical effects on the optic nerve head |
17:50 - 18:10 | Dorota Skoronska-Krawczyk | Effects of transient IOP fluctuations on the retina - apoptosis, senescence and epigenetic responses |
18:10 - 18:30 | David Krizaj | Mechanotransduction, calcium and RGC synapses |
18:30 - 18:50 | Claire Mitchell | Mechanotransduction in the retina |
18:50 - 19:10 | Valery I. Shestopalov | Mechanical stress-induced cytokine storm: lessons from the spiking IOP model |
Wednesday 11th December | ||
Session 4: Regeneration | ||
Chairs: Britta Eickholt, Richard Eva | ||
8:30 - 8:50 | Oren Schuldiner | Axon degeneration and regeneration during developmental neuronal remodelling |
8:50 - 9:10 | Alexandra Byrne | Neural repair following injury or disease |
9:10 - 9:30 | Lukas Neukomm | A novel model to study low NAD+-induced neurodegeneration in Drosophila |
9:30 - 9:50 | Evan Reid | A novel function for protrudin in endosomal tubule fission and endosome-to-Golgi traffic |
9:50-10:00 | Jean-Marc Matter | Foveal RGC characteristics in fast flying birds hunting on the wing |
Group Photo + Morning Tea | ||
Session 5: Biomarkers and clinical translation | ||
Chairs: Wendy Liu, Bob Casson | ||
10:30 - 10:50 | Bob Casson | Photobiomodulation in experimental glaucoma |
10:50 - 11:10 | Wendy Liu | Mechanosensation - beyond IOP |
11:10 - 11:30 | Joana Galvao | The power of partnership: Aligning academic research and industry practices to bring innovation to glaucoma patients |
11:30 - 11:40 | Linglin Zhang | Targeting NLRP3/caspase-1 reduces pyroptosis andastrogliosis; Protecting the retina from hypoxia |
11:40 - 11:50 | Luca Masin | Local glycolysis as a gatekeeper of injury-induced axonal regrowth |
Lunch Break | ||
Session 6: RGC metabolism and injury | ||
Chairs: Lukas Neukomm, Marcella Votruba | ||
17:30 - 17:50 | Tudor Badia | A novel glucose transporter regulator expressed in RGC subpopulations |
17:50 - 18:10 | Shweta Singhal | Understanding the cellular mechanisms underlying Ethambutol Optic Neuropathy using stem cell derived RGCs |
18:10 - 18:30 | Andrea Loreto | NAD: the good the bad and the ugly |
18:30 - 18:50 | Wenting You | In vitro studies to explore the potential of rescuing dying RGCs |
18:50 - 19:10 | Britta Eickholt | Astrocyte reactivity and neuroinflammation: The role of LRRK2 and Rab8 in injury pathways |
Thursday 12th December | ||
Session 7: Transplantation and regeneration | ||
Chairs: Thora Karadottir, Jeff Goldberg | ||
8:30 - 8:50 | Jeff Goldberg | RGC transplant and anatomic and functional integration |
8:50 - 9:10 | Tom Johnson | Functional synaptic integration of transplanted retinal ganglion cells |
9:10 - 9:30 | Luciano Custo-Grieg | Developmental in vivo screen delineates transcriptional controls and gene regulatory networks capable of directing RGC differentiation |
9:30 - 9:50 | Larry Benovitz | The mouse model of optic nerve regeneration: novel effectors |
9:50 - 10:00 | Bart Nieuwenhuis | Endoplasmic reticulum as target for optic nerve regeneration |
Morning Tea | ||
Session 8: Gene therapy and novel therapeutic approaches | ||
Chairs: Tom Johnson, Katharina Bell | ||
10:30 - 10:50 | András Komáromy | Canine primary open-angle glaucoma – updates on an established model |
10:50 - 11:10 | Volker Patzel | Non-viral vectors for mitochondrial gene therapy -a potential approach for optic nerve disease |
11:10 - 11:30 | Nick Marsh-Armstrong | Myeloid cell ablation phenocopies the axon preservation due to NAD+ augmentation |
11:30 - 11:50 | Pete Williams | Gene therapy and pharmacological targeting of NMNAT2 in glaucoma |
11:50 - 12:00 | Andrew White | Axonal mitochondria preservation by angiotensin receptor blockers in a rodent optic nerve crush model |
Lunch Break | ||
Session 9: In vivo imaging and organoids | ||
Chairs: Jonathan Crowston, Anna Wang | ||
17:30 - 17:50 | Luis Alarcon-Martinez | Alterations of the flux pattern in glaucoma: mismatch between supply and demand |
17:50 - 18:10 | Anna Wang | Functional imaging of the optic nerve with 2-photon microscopy in living mice |
18:10 - 18:30 | Erik Ullian | Investigating neurodegeneration in the brain and retina using assembled iPSC organoid models and CRISPRi |
18:30 - 18:50 | Robert Zawadzki | Progress on in vivo retinal and ONH imaging in animal models |
18:50 - 19:00 | Gloria Cimaglia | Use of Retinal Ganglion Cell for detection of early dysfunction in LRRK2 Parkinsonian models |