Optic Nerve Meeting 2024

10-12 December

 AGENDA 

 

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20 minute slot = 10 minute talk and 10 minute discussion
10 minute slot  = 5 minute talk and 5 minute discussion
Tuesday 10th December
8:30 - 8:40 Jonathan, Keith & Franz Welcome and Introduction
  Session 1: Glia
  Chairs: Keith Martin, Franz Grus
8:40 - 9:00 Tom Reh Müller glia can be reprogrammed to make retinal ganglion cells; now what?
9:00 - 9:20 Michel Cayouette Retinal glia regulate the development and function of ipRGCs
9:20 - 9:40 Tatjana Jakob Alpha retinal ganglion cell to microglia signaling in glaucoma
9:40 -10:00 Thora Karadottir Oligodendrocytes and ageing
     
  Morning Tea  
     
  Session 2: Autophagy and mitochondria
  Chairs: Christian Behl, Pete Williams
10:30 - 10:50 Hagen Körschgen Unraveling BAG3-mediated aggrephagy - implications for neurodegeneration
10:50 - 11:10 Marcella Votruba NAM as a neuroprotective therapeutic intervention for mitochondrial optic neuropathies
11:10 - 11:30 Elena Vecino Implications of mitochondria in the neuroprotection and neuroregeneration of RGCs
11:30 - 11:50 Katharina Bell Effect of age on the senescence transcriptome in mouse and human retina
11:50 - 12:00 Xandra Pereiro TRPV4 modulation in Müller glia: Impact on gliosis and retinal cell survival
     
  Lunch Break  
     
  Session 3: Transient IOP fluctuations - do they matter?
  Chairs: Crawford Downs, Claire Mitchell
17:30 - 17:50 Crawford Downs Intraocular and cerebrospinal pressure fluctuations: Biomechanical effects on the optic nerve head
17:50 - 18:10 Dorota Skoronska-Krawczyk Effects of transient IOP fluctuations on the retina - apoptosis, senescence and epigenetic responses
18:10 - 18:30 David Krizaj Mechanotransduction, calcium and RGC synapses
18:30 - 18:50 Claire Mitchell Mechanotransduction in the retina
18:50 - 19:10 Valery I. Shestopalov  Mechanical stress-induced cytokine storm: lessons from the spiking IOP model
     
Wednesday 11th December
  Session 4: Regeneration
  Chairs: Britta Eickholt, Richard Eva
8:30 - 8:50 Oren Schuldiner Axon degeneration and regeneration during developmental neuronal remodelling
8:50 - 9:10 Alexandra Byrne Neural repair following injury or disease
9:10 - 9:30 Lukas Neukomm A novel model to study low NAD+-induced neurodegeneration in Drosophila
9:30 - 9:50 Evan Reid A novel function for protrudin in endosomal tubule fission and endosome-to-Golgi traffic
9:50-10:00 Jean-Marc Matter Foveal RGC characteristics in fast flying birds hunting on the wing
     
  Group Photo + Morning Tea
     
  Session 5: Biomarkers and clinical translation
  Chairs: Wendy Liu, Bob Casson
10:30 - 10:50 Bob Casson Photobiomodulation in experimental glaucoma
10:50 - 11:10 Wendy Liu Mechanosensation - beyond IOP
11:10 - 11:30 Joana Galvao The power of partnership: Aligning academic research and industry practices to bring innovation to glaucoma patients
11:30 - 11:40 Linglin Zhang Targeting NLRP3/caspase-1 reduces pyroptosis andastrogliosis; Protecting the retina from hypoxia 
11:40 - 11:50 Luca Masin Local glycolysis as a gatekeeper of injury-induced axonal regrowth
     
  Lunch Break  
     
  Session 6: RGC metabolism and injury
  Chairs: Lukas Neukomm, Marcella Votruba
17:30 - 17:50 Tudor Badia A novel glucose transporter regulator expressed in RGC subpopulations
17:50 - 18:10 Shweta Singhal Understanding the cellular mechanisms underlying Ethambutol Optic Neuropathy using stem cell derived RGCs
18:10 - 18:30 Andrea Loreto NAD: the good the bad and the ugly
18:30 - 18:50 Wenting You In vitro studies to explore the potential of rescuing dying RGCs
18:50 - 19:10 Britta Eickholt Astrocyte reactivity and neuroinflammation: The role of LRRK2 and Rab8 in injury pathways
     
Thursday 12th December
  Session 7: Transplantation and regeneration
  Chairs: Thora Karadottir, Jeff Goldberg
8:30 - 8:50 Jeff Goldberg RGC transplant and anatomic and functional integration
8:50 - 9:10 Tom Johnson Functional synaptic integration of transplanted retinal ganglion cells
9:10 - 9:30 Luciano Custo-Grieg Developmental in vivo screen delineates transcriptional controls and gene regulatory networks capable of directing RGC differentiation
9:30 - 9:50 Larry Benovitz The mouse model of optic nerve regeneration: novel effectors
9:50 - 10:00 Bart Nieuwenhuis  Endoplasmic reticulum as target for optic nerve regeneration
     
  Morning Tea  
     
  Session 8: Gene therapy and novel therapeutic approaches
  Chairs: Tom Johnson, Katharina Bell
10:30 - 10:50 András Komáromy Canine primary open-angle glaucoma – updates on an established model
10:50 - 11:10 Volker Patzel Non-viral vectors for mitochondrial gene therapy -a potential approach for optic nerve disease
11:10 - 11:30 Nick Marsh-Armstrong Myeloid cell ablation phenocopies the axon preservation due to NAD+ augmentation
11:30 - 11:50 Pete Williams Gene therapy and pharmacological targeting of NMNAT2 in glaucoma
11:50 - 12:00 Andrew White Axonal mitochondria preservation by angiotensin receptor blockers in a rodent optic nerve crush model
     
  Lunch Break  
     
  Session 9:  In vivo imaging and organoids
  Chairs: Jonathan Crowston, Anna Wang
17:30 - 17:50 Luis Alarcon-Martinez Alterations of the flux pattern in glaucoma: mismatch between supply and demand
17:50 - 18:10 Anna Wang Functional imaging of the optic nerve with 2-photon microscopy in living mice
18:10 - 18:30 Erik Ullian Investigating neurodegeneration in the brain and retina using assembled iPSC organoid models and CRISPRi
18:30 - 18:50 Robert Zawadzki Progress on in vivo retinal and ONH imaging in animal models
18:50 - 19:00 Gloria Cimaglia Use of Retinal Ganglion Cell for detection of early dysfunction in LRRK2 Parkinsonian models