| 20 minute slot = 10 minute talk and 10 minute discussion |
| 10 minute slot = 5 minute talk and 5 minute discussion |
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| Tuesday 10th December |
| 8:30 - 8:40 |
Jonathan, Keith & Franz |
Welcome and Introduction |
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Session 1: Glia |
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Chairs: Keith Martin, Franz Grus |
| 8:40 - 9:00 |
Tom Reh |
Müller glia can be reprogrammed to make retinal ganglion cells; now what? |
| 9:00 - 9:20 |
Michel Cayouette |
Retinal glia regulate the development and function of ipRGCs |
| 9:20 - 9:40 |
Tatjana Jakob |
Alpha retinal ganglion cell to microglia signaling in glaucoma |
| 9:40 -10:00 |
Thora Karadottir |
Oligodendrocytes and ageing |
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Morning Tea |
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Session 2: Autophagy and mitochondria |
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Chairs: Christian Behl, Pete Williams |
| 10:30 - 10:50 |
Hagen Körschgen |
Unraveling BAG3-mediated aggrephagy - implications for neurodegeneration |
| 10:50 - 11:10 |
Marcella Votruba |
NAM as a neuroprotective therapeutic intervention for mitochondrial optic neuropathies |
| 11:10 - 11:30 |
Elena Vecino |
Implications of mitochondria in the neuroprotection and neuroregeneration of RGCs |
| 11:30 - 11:50 |
Katharina Bell |
Effect of age on the senescence transcriptome in mouse and human retina |
| 11:50 - 12:00 |
Xandra Pereiro |
TRPV4 modulation in Müller glia: Impact on gliosis and retinal cell survival |
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Lunch Break |
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Session 3: Transient IOP fluctuations - do they matter? |
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Chairs: Crawford Downs, Claire Mitchell |
| 17:30 - 17:50 |
Crawford Downs |
Intraocular and cerebrospinal pressure fluctuations: Biomechanical effects on the optic nerve head |
| 17:50 - 18:10 |
Dorota Skoronska-Krawczyk |
Effects of transient IOP fluctuations on the retina - apoptosis, senescence and epigenetic responses |
| 18:10 - 18:30 |
David Krizaj |
Mechanotransduction, calcium and RGC synapses |
| 18:30 - 18:50 |
Claire Mitchell |
Mechanotransduction in the retina |
| 18:50 - 19:10 |
Valery I. Shestopalov |
Mechanical stress-induced cytokine storm: lessons from the spiking IOP model |
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| Wednesday 11th December |
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Session 4: Regeneration |
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Chairs: Britta Eickholt, Richard Eva |
| 8:30 - 8:50 |
Oren Schuldiner |
Axon degeneration and regeneration during developmental neuronal remodelling |
| 8:50 - 9:10 |
Alexandra Byrne |
Neural repair following injury or disease |
| 9:10 - 9:30 |
Lukas Neukomm |
A novel model to study low NAD+-induced neurodegeneration in Drosophila |
| 9:30 - 9:50 |
Evan Reid |
A novel function for protrudin in endosomal tubule fission and endosome-to-Golgi traffic |
| 9:50-10:00 |
Jean-Marc Matter |
Foveal RGC characteristics in fast flying birds hunting on the wing |
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Group Photo + Morning Tea |
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Session 5: Biomarkers and clinical translation |
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Chairs: Wendy Liu, Bob Casson |
| 10:30 - 10:50 |
Bob Casson |
Photobiomodulation in experimental glaucoma |
| 10:50 - 11:10 |
Wendy Liu |
Mechanosensation - beyond IOP |
| 11:10 - 11:30 |
Joana Galvao |
The power of partnership: Aligning academic research and industry practices to bring innovation to glaucoma patients |
| 11:30 - 11:40 |
Linglin Zhang |
Targeting NLRP3/caspase-1 reduces pyroptosis andastrogliosis; Protecting the retina from hypoxia |
| 11:40 - 11:50 |
Luca Masin |
Local glycolysis as a gatekeeper of injury-induced axonal regrowth |
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Lunch Break |
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Session 6: RGC metabolism and injury |
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Chairs: Lukas Neukomm, Marcella Votruba |
| 17:30 - 17:50 |
Tudor Badia |
A novel glucose transporter regulator expressed in RGC subpopulations |
| 17:50 - 18:10 |
Shweta Singhal |
Understanding the cellular mechanisms underlying Ethambutol Optic Neuropathy using stem cell derived RGCs |
| 18:10 - 18:30 |
Andrea Loreto |
NAD: the good the bad and the ugly |
| 18:30 - 18:50 |
Wenting You |
In vitro studies to explore the potential of rescuing dying RGCs |
| 18:50 - 19:10 |
Britta Eickholt |
Astrocyte reactivity and neuroinflammation: The role of LRRK2 and Rab8 in injury pathways |
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| Thursday 12th December |
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Session 7: Transplantation and regeneration |
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Chairs: Thora Karadottir, Jeff Goldberg |
| 8:30 - 8:50 |
Jeff Goldberg |
RGC transplant and anatomic and functional integration |
| 8:50 - 9:10 |
Tom Johnson |
Functional synaptic integration of transplanted retinal ganglion cells |
| 9:10 - 9:30 |
Luciano Custo-Grieg |
Developmental in vivo screen delineates transcriptional controls and gene regulatory networks capable of directing RGC differentiation |
| 9:30 - 9:50 |
Larry Benovitz |
The mouse model of optic nerve regeneration: novel effectors |
| 9:50 - 10:00 |
Bart Nieuwenhuis |
Endoplasmic reticulum as target for optic nerve regeneration |
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Morning Tea |
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Session 8: Gene therapy and novel therapeutic approaches |
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Chairs: Tom Johnson, Katharina Bell |
| 10:30 - 10:50 |
András Komáromy |
Canine primary open-angle glaucoma – updates on an established model |
| 10:50 - 11:10 |
Volker Patzel |
Non-viral vectors for mitochondrial gene therapy -a potential approach for optic nerve disease |
| 11:10 - 11:30 |
Nick Marsh-Armstrong |
Myeloid cell ablation phenocopies the axon preservation due to NAD+ augmentation |
| 11:30 - 11:50 |
Pete Williams |
Gene therapy and pharmacological targeting of NMNAT2 in glaucoma |
| 11:50 - 12:00 |
Andrew White |
Axonal mitochondria preservation by angiotensin receptor blockers in a rodent optic nerve crush model |
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Lunch Break |
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Session 9: In vivo imaging and organoids |
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Chairs: Jonathan Crowston, Anna Wang |
| 17:30 - 17:50 |
Luis Alarcon-Martinez |
Alterations of the flux pattern in glaucoma: mismatch between supply and demand |
| 17:50 - 18:10 |
Anna Wang |
Functional imaging of the optic nerve with 2-photon microscopy in living mice |
| 18:10 - 18:30 |
Erik Ullian |
Investigating neurodegeneration in the brain and retina using assembled iPSC organoid models and CRISPRi |
| 18:30 - 18:50 |
Robert Zawadzki |
Progress on in vivo retinal and ONH imaging in animal models |
| 18:50 - 19:00 |
Gloria Cimaglia |
Use of Retinal Ganglion Cell for detection of early dysfunction in LRRK2 Parkinsonian models |
