| 20 minute slot = 10 minute talk and 10 minute discussion |
| 10 minute slot = 5 minute talk and 5 minute discussion |
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| Tuesday 9th December |
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Session 1: Glial Influence in Optic Neuropathy |
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Chairs: Adriana Di Polo, Lukas Neukomm |
| 8:30 - 8:40 |
Keith, Jonathan & Franz |
Welcome and Introduction |
| 8:40 - 9:00 |
Qi Cui |
Fate mapping determines the roles of monocytes and microglia in glaucoma |
| 9:00 - 9:20 |
Deborah Villafranca |
cAMP Signaling and spatially resolved astrocyte diversity in glaucoma |
| 9:20 - 9:40 |
James Tribble |
Inflammation-driven metabolic dysfunction |
| 9:40 - 9:50 |
Xandra Pereiro |
Müller glia–RGC communication via extracellular vesicles |
| 9:50 - 10:00 |
Athanasios Alexandris |
Axonal degeneration and recovery after diffuse traumatic optic nerve injury: evidence for homotypic collateral sprouting and sex-dependent plasticity |
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Morning Tea |
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Session 2: Mitochondrial Dysfunction and Metabolism |
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Chairs: Elena Vecino, Franz Grus |
| 10:30 - 10:50 |
Bledi Petriti |
Reversing mitochondrial dysfunction in optineurin E50K glaucoma |
| 10:50 - 11:10 |
Jeff Goldberg |
Axon transport of mitochondria and mRNAs |
| 11:10 - 11:30 |
Elena Vecino |
Mitochondrial importance in RGC injury and repair |
| 11:30 - 11:50 |
Luana Naia |
Mitochondria-derived vesicles in ageing and neurodegeneration |
| 11:50 - 12:00 |
Yasmin Alameldin |
Mitochondrial DNA at the Interface between mitochondrial dysfunction and neuroinflammation in glaucoma |
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Lunch Break |
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Session 3: Neurodegeneration |
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Chairs: Yang Hu, Giovanna Malucci |
| 17:30 - 17:50 |
Bryan Jones |
Retina: A model for neurodegeneration |
| 17:50 - 18:10 |
Giovanna Malucci |
Neurodegeneration and protein stress |
| 18:10 - 18:30 |
Len Levin |
Axon-to-axon signaling: A paradigm for progression in optic neuropathy |
| 18:30 - 18:40 |
Jesse Gardner-Russell |
Selective axonal injury depletes interpericyte tunnelling nanotubes |
| 18:40 - 18:50 |
Lidia Sánchez-Puebla |
The retina as a mirror of Alzheimer’s Disease: Early structural and vascular alterations in the APPNL-F/NL-F mouse model |
| 18:50 - 19:00 |
Seungsoo Rho |
Nicotinamide trial in NTG patients |
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| Wednesday 10th December |
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Session 4: Regeneration and Repair Pathways |
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Chairs: Richard Eva, Luana Naia |
| 8:30 - 8:50 |
Richard Eva |
Optimising retinal neuroprotection and optic nerve regeneration by targeting axonal organelles |
| 8:50 - 9:10 |
Adriana Di Polo |
Neuronal revival: The insulin pathway to dendritic and synaptic regeneration after axonal injury |
| 9:10 - 9:30 |
Robin Franklin |
Schwann cells in the CNS |
| 9:30 - 9:50 |
Yang Hu |
Recent progress on optic nerve protection and regeneration |
| 9:50 - 10:00 |
Carola Rutigliani |
Netrin-1 as a dual guidance and regenerative cue following sheath-preserving optic nerve transection |
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Group Photo + Morning Tea |
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Session 5: Gene Therapy and Translational Platforms |
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Chairs: Alice Pébay, Keith Martin |
| 10:30 - 10:50 |
Volker Patzel |
Non-viral vectors for mitochondrial gene therapy |
| 10:50 - 11:10 |
Alice Pébay |
Can we use iPSCs to characterise heterogeneity in AMD? The case of reticular pseudodrusen |
| 11:10 - 11:30 |
Pete Williams |
Gene therapy targeting neuroprotection and neuroregeneration in glaucoma |
| 11:30 - 11:50 |
Stavros Vagionitis |
Neuronal activity bidirectionally regulates myelin plasticity |
| 11:50 - 12:00 |
Steven Bergmans |
A proof-of-concept study for single-nucleotide base editing to prevent vision loss in a Wolfram Syndrome mouse model |
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Lunch Break |
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Session 6: Vision Circuits and Synaptic Plasticity |
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Chairs: Pete Williams, Deborah Villafranca |
| 17:30 - 17:50 |
Ben Sivyer |
Melanopsin in high-acuity RGCs |
| 17:50 - 18:10 |
Tas Khatib |
CNTF-mediated rescue of circuit dysfunction |
| 18:10 - 18:30 |
Christian van Oterendorp |
Mechanosensitive responses of cultured RGCs |
| 18:30 - 18:50 |
Luca Masin |
Successful injury-induced axonal regeneration requires extensive dendritic remodelling |
| 18:50 - 19:00 |
Greg Duncan |
Remyelination protects retinal ganglion cells from dual leucine zipper kinase-mediated apoptosis |
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| Thursday 11th December |
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Session 7: Rapid-Fire |
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Chairs: Michel Cayouette, Len Levin |
| 8:30 - 8:40 |
Andrew White |
Role of Lactoferrin on RGC survival in a retinal explant model |
| 8:40 - 8:50 |
Alan Nicol |
Pyrroloquinoline quinone is a potent metabo- and gero- protective agent in C. elegans |
| 8:50 - 9:00 |
Marcelino Aviles-Trigueros |
Unveiling hidden complexity: Insights into an uncharacterized subtype of retinal ganglion cell |
| 9:00 - 9:10 |
Ngan Pan Bennett Au |
Neuronal-intrinsic mechanisms for effective nerve repair: therapeutic implications for glaucoma |
| 9:10 - 9:20 |
Xiaosha Wang |
Crybb3 promotes retinal ganglion cell axon regeneration via mTOR pathway activation |
| 9:20 - 9:30 |
Qiong Ding |
Evaluating AMPK activation as a strategy to enhance retinal ganglion cell survival and function in glaucoma |
| 9:30 - 9:40 |
Marta Molinari |
Modulation of miR-181a/b prevents glaucomatous optic neuropathy by improving mitochondrial dynamics and suppressing inflammation |
| 9:40 - 9:50 |
Markus Kuehn |
Altered distribution of T Cells in peripheral blood of patients with POAG |
| 9:50 - 10:00 |
Valery I. Shestopalov |
Inflammasome blockade strategies in optic neuropathies |
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Morning Tea |
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Session 8: Neuroprotection |
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Chairs: Jeff Goldberg, Katharina Bell |
| 10:30 - 10:50 |
Antje Grosche |
TSPO maintains Müller Cell metabolic resilience under stress to preserve retinal homeostasis |
| 10:50 - 11:10 |
Livia Carvalho |
Drug-based interventions for cone preservation |
| 11:10 - 11:30 |
John D. Ash |
AMPK and mitochondria-targeted neuroprotection |
| 11:30 - 11:50 |
Veronica Moreno |
Cell type-targeted mitochondrial transplantation mediated by protein binders rescues cell degeneration |
| 11:50 - 12:00 |
Eleonora Daghini |
Targeting taurine metabolism for neuroprotection in a rat model of ocular hypertensive glaucoma |
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Lunch Break |
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Session 9: Transplantation, Stem cells and Organoid Models |
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Chairs: Tas Khatib, Andrea Loreto |
| 17:30 - 17:50 |
Tim Kennedy |
Making connections: guiding synaptic plasticity in the CNS |
| 17:50 - 18:10 |
Michel Cayouette |
Numb-mediated Tau lowering therapy |
| 18:10 - 18:30 |
Luis Alarcon-Martinez |
Specialised neuronal areas and blood supply: more than functional hyperemia |
| 18:30 - 18:50 |
Keith, Jonathan & Franz |
Close and suggestions for 2026 |
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