Optic Nerve Meeting 2018 11-13 December

Obergurgl, Austria  





  Tuesday 11 December  
8:20 - 8:30 Jonathan Crowston, Franz Grus & Keith Martin Welcome and Introduction
  Session I: Bioenergetics  
  Moderators: Pete Williams & Jonathan Crowston  
8:30 - 8:50 Peter van Wijngaarden Bioenergetics of the optic nerve
8:50 - 9:10 Pete WIlliams Targeting neuronal mitochondria for neuroprotection in glaucoma
9:10 - 9:30 Grace Zhai A balance of NAD+ metabolism and proteostasis in NMNAT_mediated neuroprotection
9:30 - 9:50 Guy Lenaers Genetic, physiopathology and metabolic analyses of dominant optic neuropathies, towards defining future therapies
  Morning Tea  
  Session II: Inner Retina and Optic Nerve Regeneration
  Moderators: Bryan Jones & Keith Martin  
10:30 - 10:50 Richard Eva Enabling optic nerve regerneration through the mobilisation of axon growth machinery
10:50 - 11:10 Lieve Moons Inflammatory stimulation as fuel for axon regeneration: elucidating underlying cellular and molecular players
11:10 - 11:30 Michel Cayouette Regulating intraneuronal Tau levels in retinal ganglion cells
11:30 - 11:40 Tasneem Khatib Axon transport and regeneration following glaucomatous injury
11:40 - 11:50 Rachel Evans Manipulation of the PI3-kinase pathway to promote RGC axon regeneration in vivo using the optic nerve crush model
  Lunch Break  
  Session III: Autophagy  
  Moderators: Katharina Bell & Christian Behl  
17:30 - 17:50 Albrecht Clement DNAJC13, a Parkinson’s disease-associated gene, modulates autophagy
17:50 - 18:10 Jochen Weishaupt Molecular genetics of the ALS- and glaucoma-associated TBK1
18:10 - 18:30 Christian Behl Autophagy as adaptive process in neuronal cells
18:30 - 18:50 Christian Behrends Identifying machinery and cargo of selective autophagy
  Wednesday 12 December  
  Session IV: Neuroinflammation  
  Moderators: Franz Grus & Miriam Kolko  
8:30 - 8:50 Miriam Kolko Systemic implications of glaucomatous optic neuropathy
8:50 - 9:10 Alyson Fournier 14-3-3 proteins and CNS regeneration
9:10 - 9:30 Katharina Bell 14-3-3 proteins in glaucoma
9:30 - 9:40 Carsten Schmelter CDR peptides in glaucoma
9:40 - 9:50 Vanessa Beutgen Analysis of autoantibodies in glaucoma subtypes
  Morning Tea  
  Session V: Electirical Activity to Neuronal Biointerfaces
  Moderators: Manohar Bance & Damiano Barone  
10:30 - 10:50 Manohar Bance Machine-neural interfaces in auditory disorders
10:50 - 11:10 Damiano Barone Restoring lost function: chellenges and prospects in neural interface technology
11:10 - 11:30 Alejandro Carnicer Mechano-biology challenges in neuro-prosthetics and peripheral nerve injury
11:30 - 11:40 Christian van Oterendorp Influence of polyacrylamide gel substrates on primary retinal ganglion cell culture
  Lunch Break  
  Session VI: Innovation and Translation  
  Moderators: Darren Kelly  
17:30 - 17:50 Leonard Levin Challenges to translating treatments for optic neuropathies
17:50 - 18:10 Darren Kelly Molecules to medicine: lessons from developing antifibrosis drugs for eye disease
18:10 - 18:30 David Mackey Glaucoma genetics - what it tells us about disease pathogenesis
18:30 - 18:40 Jessica Tang The short-term effect of intraocular pressure reduction on the photopic negative response in glaucoma
  Thursday 13 December  
  Session VII: Glial-Neural Interactions  
  Moderators: Thora Karadottir & Andras Lakatos  
8:30 - 8:50 Andras Lakatos Neuronal help-me signals in astrocyte-mediated repair and neurodegeneration
8:50 - 9:10 Tom Johnson Retinal integration of transplanted stem cells as a fundamental step towards RGC replacement therapy
9:10 - 9:30 Aiman Saab Studying axon-glial signaling and axonal energy metabolism in the optic nerve
9:30 - 9:50 Sarah Förster Functional heterogeneity of oligodendrocytes in the CNS
9:50 - 10:00 Seungsoo Rho Chronic ocular hypertensive rat model using various microbeads
  Morning Tea  
  Session VIII: Sick Ganglion Cells  
  Moderators: Leonard Levin & Elena Veccino  
10:30 - 10:50 Claire Mitchell Linking IOP elevation to microglial cell activation through ATP
10:50 - 11:10 Elena Veccino How Müller glía help RGCs
11:10 - 11:30 Grace Lidgerwood Engineering a human reitna in a dish using patient IPSC -derived retinal cells
11:30 - 11:50 Vicki Chysostomou Exercise promotes RGC functional recovery
11:50 - 12:00 Daun Jeong Effect of refractive error on the physiologic thinning rate of retinal nerve fiber layer in healthy eyes
  Lunch Break  
  Session IX:  Synaptic Remodelling  
  Moderators: James Morgan  
17:30 - 17:50 James Morgan Dendritic remodelling in human glaucoma
17:50 - 18:10 Bryan Jones Connectomics frameworks for ganglion cell connectivity
18:10 - 18:20 Yuhong Dong Preliminary observations from a pilot study on the effects of SRG003 in spontaneous idiopathic Optic Atrophy in the rhesus monkey 
  Keith, Franz and Jonathan Brief wrap up and solicit suggestions for next Obergurgl 2019