| Tuesday 12th December |
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8:30 - 8:50 |
Jonathan Keith & Franz |
Welcome and Introduction |
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Session 1: Axon Degeneration |
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Chairs: Keith Martin, Franz Grus |
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8:50 - 9:10 |
Andrea Loreto |
NMN in axon degeneration and ageing |
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9:10 - 9:30 |
Lukas Neukomm |
Wallerian degeneration in Drosophila |
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9:30 - 9:50 |
Lies De Groef |
Preventing optic nerve degeneration in Wolfram syndrome: proof-of-concept study of base editing in mouse and iPSC models |
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9:50 -10:00 |
Caroline Manicam |
Cell Signalling and (Patho)physiological Implications of Ocular Neurovascular Adaptive Mechanisms |
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Morning Tea |
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Session 2: Glia |
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Chairs: Elena Veccino, Andras Lakatos |
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10:30 - 10:50 |
Gloria Cimaglia |
Microglia inhibition in glaucoma – be careful what you wish for |
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10:50 - 11:10 |
Andras Lakatos |
Loss of astrocyte function in neurodegeneration – novel aspects emerging from 2D/3D human models |
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11:10 - 11:30 |
Tatjana Jakobs |
Astrocyte-derived factors for neuroprotection in age and glaucoma |
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11:30 - 11:50 |
Daniel Sun |
Optic nerve astrocytes exhibit a region-specific and temporally distinct response to ocular hypertension |
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11:50 - 12:00 |
Xandra Pereiro |
Müller glia as neuroprotector in the retina |
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Lunch Break |
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Session 3: Physiology |
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Chairs: Tom Reh, Sara Thomasy |
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17:30 - 17:50 |
Chris Girkin |
Impact of acute and prolonged IOP elevation in the living human eye |
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17:50 - 18:10 |
Crawford Downs |
Intraocular and Cerebrospinal Pressure Dynamics: Implications for Ocular Health and Disease |
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18:10 - 18:30 |
Leo Schmetterer |
Structure-function relationships |
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18:30 - 18:50 |
Luis Alarcon-Martinez |
Interpericyte tunneling nanotubes as regulators of the blood flow distribution in the retina and optic nerve head |
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18:50 - 19:00 |
Steffi Jonk |
Metabolic analysis of mouse sarcopenic skeletal muscle identifies new strategies to increase lifespan in C. elegans |
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Wednesday 13th December |
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Session 4: Repair & Replacement |
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Chairs: Jonathan Crowston, Claire Mitchell |
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8:30 - 8:50 |
Ben Sivyer |
Towards RGC replacement for treating glaucoma |
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8:50 - 9:10 |
Richard Eva |
ER and Golgi as targets for repair and protection |
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9:10 - 9:30 |
Claire Mitchell |
Piezo channels, pressure and inflammation in RGCs and glia |
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9:30 - 9:40 |
James Tribble |
B-vitamin treatment provides neuroprotection in glaucoma by mitigating homocysteine and one-carbon metabolism disruption |
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9:40 - 9:50 |
Christian van Oterendorp |
Mechanosensitivity of retinal ganglion cells |
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Group Photo + Morning Tea |
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Session 5: Regeneration |
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Chairs: Nick Marsh-Armstrong, Michael Kapiloff |
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10:30 - 10:50 |
Tom Reh |
Reprogramming Muller glia to regenerate ganglion cells: improving differentiation and integration. |
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10:50 - 11:10 |
Michel Cayouette |
Transcriptional control of contralateral retinal ganglion cell projections |
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11:10 - 11:30 |
Britta Eickholt |
Coordinating Axon Growth with Axon Branching |
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11:30 - 11:50 |
Steven Bergmans |
Atypical response to optic nerve injury in a unique fast ageing animal model |
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11:50 - 12:10 |
Gerhard Garhofer |
Pearls for early phase neuroprotection studies |
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Lunch Break |
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Session 6: Ageing and Degeneration |
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Chairs: Marcela Votruba, Michel Cayouette |
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18:00 - 18:20 |
Oliver Gramlich |
Antibody-mediated optic neuropathies |
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18:20 - 18:40 |
David Mackey |
Assessing the risk of vision loss in LHON mutation carriers for enrollment in prevention trials. |
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18:40 - 18:50 |
Andrew White |
Angiotensin receptor blockers confer neuroprotection in a rodent optic nerve crush model |
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18:50 - 19:00 |
Melissa Jöe |
Development of neuroprotective small molecular drugs targeting NMNAT2 |
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Thursday 14th December |
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Session 7: Neuroprotection |
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Chairs: Britta Eickholt, Katharina Bell |
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8:30 - 8:50 |
Pete Williams |
NMNAT2 is a druggable target to increase neuronal NAD |
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8:50 - 9:10 |
Len Levin |
Modeling Mechanisms for Neuroprotective Phosphine-Boranes |
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9:10 - 9:30 |
Michael Kapiloff |
CaMKII – RGC neuroprotection and axon regeneration |
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9:30 - 9:50 |
Rossella Russo |
Modulation of autophagy: a potential strategy for RGC neuroprotection in glaucoma |
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9:50 - 10:00 |
Seungsoo Rho |
Dendritic pruning versus soma loss in a mouse glaucoma model |
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Morning Tea |
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Session 8: Super Models & Crowded Spaces |
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Chairs: Andrea Loreto, Lies De Groef |
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10:30 - 10:50 |
Elena Vecino |
The effect of the whale Müller glia on the RGC axonal regeneration |
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10:50 - 11:10 |
Sara Thomasy |
Update on a Nonhuman Primate Model of Autosomal Dominant Optic Atrophy |
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11:10 - 11:30 |
Yang Hu |
Glaucoma models and beyond |
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11:30 - 11:50 |
Jesse Gale |
The most geological of optic neuropathies |
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11:50 - 12:00 |
Anne Rombaut |
Intravitreal injection of MPTP leads to retinal ganglion cell death in the absence of a Parkinson's disease-like phenotype |
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Lunch Break |
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Session 9: Protecting the CNS |
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Chairs: Leo Schmetterer, Len Levin |
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17:30 - 17:50 |
Volker Patzel |
Design and delivery of functional RNA for treatment of optic neuropathies |
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17:50 - 18:10 |
Jeff Goldberg |
Update on clinical trials in glaucoma neuroprotection |
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18:10 - 18:30 |
Christian Behl |
Rethinking Alzheimer's disease research |
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18:30 - 18:50 |
Dan Milea |
Through the optic nerve into the brain using AI |
