Tuesday 13 December

Welcome and Introduction

Jonathan Crowston, Franz Grus & Keith Martin

Session I: RGC Injury and Repair

Moderators: Andras Lakatos & Elena Vecino

RGC dysfunction before death in primate glaucoma

Ben Sivyer

From repair to degeneration

Vicki Chrysostomou

Inversion as a provocative test of ocular biomechanics

Jesse Gale

Can we block axon degeneration in disease?

Andrea Loreto

Development of neuroprotective small molecular drugs targeting NMNAT2

Melissa Jöe

Morning Tea

Session II: Neurodegeneration

Moderators: Adriana Di Polo & Jesse Gale

BDNF and platelets (ONC and explants)

James Morgan

Phospholipids and the Signaling of Axoptosis

Len Levin

Photobiomodulation

Bob Casson

The co-chaperone BAG3 as hub for selective autophagy on demand

Christian Behl

Pyrroloquinoline quinone exerts neuroprotective effects on retinal ganglion cell degeneration

Alessio Canovai

Lunch Break

Session III: ipRGC development and functon

Moderators: Ben Sivyer

ipRGC-glia interaction during development regulates circadian photoentrainement

Michel Cayouette

Genetic underpinnings of ipRGC diversity

Tiffany Schmidt

ipRGC's role in vision

Samer Hatter

Tracing ipRGCs in the mouse brain

Nina Milosavljevic

Wednesday 14 December

Session IV: Neuroinflammation and Glia

Moderators: Franz Grus & Vicki Chrysostomou

Activity dependent myelin changes in the optic nerve

Thora Karadottir

Optic nerve astrocytes: A new axis for neuroprotection

Jeff Goldberg

Synthetic synapses to restore neural circuits

Tim Kennedy

Implication of Müller glia in Glaucoma

Elena Vecino

Glial response in the injured and contralateral retinas after unilateral optic nerve crush

Caridad Galindo-Romero

Morning Tea

Session V: Recycling, Regeneration and Replacement

Moderators: Keith Martin & Caroline Manicam

Targeting ER to golgi traffic for retinal neuroprotection and optic nerve regeneration

Richard Eva

Deconstructing successful axonal regeneration

Nick Marsh-Armstrong

Intraneuronal and intercellular communication drive optic nerve regeneration

Lieve Moons

Intermittent fasting drives autophagy and mitophagy in the ageing retina but does it protect?

Katharina Bell

Disruption of Checkpoint Genes in T-regulatory Cells Protects Retinal Ganglion Cells in Experimental Glaucoma

Markus Kuehn

Lunch Break

Session VI: Development and Regeneration

Moderators: Lieve Moons & Nick Marsh-Armstrong

Regenerating new functional ganglion cells from Muller glia in adult mouse retina

Tom Reh

Human neural organoid models: deciphering degeneration and regeneration at single cell resolution

Andras Lakatos

Molecular integration of Sonic Hedgehog, an RGC derived growth signal, into retinal development

Ed Levine

Axon guidance and target selection

Kevin Park

Glaucoma: neuroprotection trials

Stefano Gandolfi

Thursday 15 December

Session VII: Mitochondria and Metabolism

Moderators: Bob Casson & Thora Karadottir

Targeting NMNAT2 for neuroprotection in glaucoma

Pete Williams

Preventing retinal homocysteine dysregulation protects against retinal ganglion cell death

James Tribble

Mitochondrial transport deficits in glaucoma: at the center of RGC metabolic stress?

Adriana Di Polo

Oxidative stress in glaucoma

Miriam Kolko

NAM protection in the rat model

Gloria Cimaglia

Morning Tea

Session VIII: Replacement and Novel Technologies

Moderators: Tom Reh & Tiffany Schmidt

Novel RNA therapies

Volker Patzel

Mesenchymal stromal cell therapy: effect of the type of transplant

Marta Agudo-Barriuso

Engraftment of transplanted retinal ganglion cells

Tom Johnson

Novel Vascular Adaptive Mechanisms of the Ophthalmic Artery: From Cell Signalling to (Patho)physiological Implications

Caroline Manicam

Eye transplanation

Vasyly Rohovyy (patient)

Lunch Break

Session IX: Clinical Aspects

Moderators: Miriam Kolko & Len Levin

Retinal hyperspectral imaging for neurodegenerative diseases

Pete van Wijngaarden

Update on the TONE trial and current optic nerve protection trials

Wolf Lagreze & Sebastian Küchlin

Neuromodulation using a DREADD technique for glaucoma

Ahnul Ha

Functional tomography angiography: a non-invasive metabolic stress test targeting vascular regulation

Flora Hui