| 20 minute slot = 10 minute talk and 10 minute discussion |
| 10 minute slot = 5 minute talk and 5 minute discussion |
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| Tuesday 8th December |
| 8:30 - 8:40 |
Jonathan Crowston, Franz Grus & Keith Martin |
Welcome and Introduction |
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Session 1: Glial and Immune Responses in Optic Nerve Disease |
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Chairs: Julia Schaeffer, Bryan Jones |
| 8:40 - 9:00 |
Qi Cui |
Reprogramming retinal myeloid cells through sequential depletion and repopulation for glaucoma neuroprotection |
| 9:00 - 9:20 |
Ed Levine |
Promoting neurogenic reprogramming of Muller glia with electrical stimulation |
| 9:20 - 9:40 |
Adriana Di Polo |
Neurovascular dysfunction in glaucoma |
| 9:40 - 10:00 |
Jonny Kipnis |
Cellular immunotherapies for optic nerve injuries and beyond |
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| 10:00 - 10:30 |
Morning Tea |
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Session 2: Glaucoma Neuroprotection: Clinical and Therapeutic Perspectives |
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Chairs: Adriana Di Polo, Keith Martin |
| 10:30 - 10:50 |
Jeff Goldberg |
Neurotrophic factors and electrical stimulation for glaucoma neuroprotection |
| 10:50 - 11:10 |
Ben Sivyer |
Taming the midgets |
| 11:10 - 11:30 |
Song Li |
Retinal ganglion cell–microglia crosstalk in glaucoma: from debris clearance to neuroprotection |
| 11:30 - 11:50 |
Crawford Downs |
IOP fluctuations could be blinding both patients and the clinicians who treat them |
| 11:50 - 12:00 |
Lies De Groef |
Extracellular vesicles mediate neuron-glia communication during retinal neurodegeneration |
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| 12:00 - 17:30 |
Lunch Break |
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Session 3: Mitochondrial Optic Neuropathies: Mechanisms and Therapies |
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Chairs: Qi Cui, Len Levin, John Britton |
| 17:30 - 17:50 |
Valerio Carelli |
Molecular mechanisms of LHON and mitochondrial optic neuropathies |
| 17:50 - 18:10 |
Michal Minczuk |
Mitochondrial genome engineering: modelling LHON and therapeutic approaches |
| 18:10 - 18:30 |
Marcela Votruba |
Astrocytes as drivers of pathology in mitochondrial optic neuropathies |
| 18:30 - 18:50 |
Thomas Klopstock |
Current therapeutic options for LHON: idebenone and gene therapy |
| 18:50 - 19:00 |
Claudia Priglinger |
LHON: clinical phenotype |
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| Wednesday 9th December |
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Session 4: Retinal Ganglion Cell Regeneration and Neuronal Repair |
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Chairs: Claudia Priglinger, Jonathan Crowston |
| 8:30 - 8:50 |
Julia Schaeffer |
Translational regulation of CNS regeneration |
| 8:50 - 9:10 |
Tom Reh |
Recent results in retinal ganglion cell regeneration |
| 9:10 - 9:30 |
Larry Benowitz |
Intra-retinal signaling that gates optic nerve regeneration |
| 9:30 - 9:50 |
Richard Eva |
Protecting neurons by targeting Golgi stability |
| 9:50 - 10:00 |
Andrew White |
Irbesartan protects human RGCs from mitochondrial stress and preserves mouse RGC survival following optic nerve injury |
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| 10:00 - 10:30 |
Group Photo + Morning Tea |
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Session 5: Metabolic Stress and Mitochondrial Dysfunction |
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Chairs: Marcela Votruba, Valerio Carelli |
| 10:30 - 10:50 |
Bledi Petriti |
Metabolic rewiring and leak metabolism: How the E50K mutation drives ATP synthase dysfunction |
| 10:50 - 11:10 |
Elizabeth Jonas |
ATP synthase leak channel and developmental metabolism |
| 11:10 - 11:30 |
Anna La Torre |
Linking intrinsic metabolic stress to retinal ganglion cell (RGC) degeneration |
| 11:30 - 11:50 |
Pete Williams |
Pharmacological targeting of NMNAT2 for neuroprotection |
| 11:50 - 12:00 |
Lucia Luengo Gutierrez |
Modelling and correction of retinal pathologies caused by mitochondrial DNA mutations via genetic engineering |
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| 12:00 - 17:30 |
Lunch Break |
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Session 6: Synaptic Plasticity and Visual Circuits |
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Chairs: Tas Khatib, Michel Cayouette |
| 17:30 - 17:50 |
Christian Behl |
Synaptic plasticity and mitochondrial turnover |
| 17:50 - 18:10 |
Jakob van Engelhardt |
Beyond the relay: synaptic plasticity shapes visual processing in dLGN relay neurons |
| 18:10 - 18:30 |
Jonathan Crowston |
RGC resilience- do RGCs have the capacity for functional recovery? |
| 18:30 - 18:50 |
Benedikt Grünewald |
Neuronal and synaptic impairments in lysosomal storage disorders |
| 18:50 - 19:00 |
Sarah Teichtmeister |
Reversing synaptic deficits in a mouse model of the juvenile ceroid lipofuscinosis (JNCL) |
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| Thursday 10th December |
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Session 7: Glaucoma Neuroprotection: Molecular Targets |
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Chairs: Elizabeth Jonas, Franz Grus |
| 8:30 - 8:50 |
Andrea Loreto |
Targeting SARM1 to prevent optic nerve degeneration: Therapeutic opportunities and challenges |
| 8:50 - 9:10 |
Tas Khatib |
Modelling retinal ganglion cell injury and repair in human assembloids |
| 9:10 - 9:30 |
Jenni Vu |
Mitigating glaucomatous vision loss via GLUT3 enhancement |
| 9:30 - 9:50 |
Keith Martin |
Gene therapy for glaucoma |
| 9:50 - 10:10 |
Bob Casson |
Mapping retinal metabolism: Human data |
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| 10:10 - 10:30 |
Morning Tea |
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Session 8: Emerging Therapies and Repair Models |
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Chairs: Anna La Torre, Andrea Loreto |
| 10:30 - 10:50 |
Volker Patzel |
Mitochondria targeting RNAs |
| 10:50 - 11:10 |
Veronica Moreno |
Mitochondrial therapy for optic neuropathies |
| 11:10 - 11:30 |
Kyoungln Jung |
Effects of retinal organoid developmental stage and RGC Enrichment on transplantation outcomes |
| 11:30 - 11:50 |
Sebastian Timmler |
Myelin plasticity in optic nerve ageing |
| 11:50 - 12:00 |
Stavros Vagionitis |
Neuronal activity bidirectionally regulates myelin plasticity |
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| 12:00 - 17:30 |
Lunch Break |
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Session 9: Retinal and Optic Nerve Neurodegeneration |
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Chairs: Veronica Moreno, Christian Behl |
| 17:30 - 17:50 |
Bryan Jones |
Retina: A model for neurodegeneration |
| 17:50 - 18:10 |
Kalyan Vinnakota |
Genome scale metabolic network modeling of the retina and the optic nerve |
| 18:10 - 18:30 |
Len Levin |
Dynamic molecules: Computational approaches to understanding mtDNA-associated optic neuropathies |
| 18:30 - 18:50 |
James Tribble |
TNFα, IL1α, and C1q drive rapid metabolic changes in the retina and optic nerve |
| 18:50 - 19:00 |
Jonathan Crowston, Franz Grus & Keith Martin |
Close and suggestions for 2027 |
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