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Tuesday 10 December |
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| 8:30 - 8:40 |
Jonathan Crowston, Franz Grus & Keith Martin |
Welcome and Introduction |
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Session I: Astrocytes |
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Moderators: Andras Lakatos & Elena Vecino |
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| 8:40 - 8:50 |
Andras Lakatos |
Is there a point in studying interspecies differences in astrocyte biology and pathology? |
| 8:50 - 9:10 |
Lea Wenger |
New tools for investigating human astrocyte diversity and reactivity |
| 9:10 - 9:30 |
Colleen Limegrover |
Astrocyte responses in human traumatic brain injury |
| 9:30 - 9:50 |
David Krizaj |
Neuronal and glial mechanotransduction: from retinal tension to dysfunction |
| 9:50 - 10:00 |
Eirini Kokkali |
When is a control eye not a control eye? Reactive microglia persist throughout the control contralateral visual pathway in experimental glaucoma |
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Morning Tea |
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Session II: Bioenergetics and Neuron-Glial Interactions |
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Moderators: Bob Casson & Pete Williams |
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| 10:30 - 10:50 |
Pete Williams |
From form to function: the effect of nicotinamide on retinal ganglion cell metabolism and mitochondria |
| 10:50 - 11:10 |
Bob Casson |
Gene therapy with neuroglobin in experimental glaucoma |
| 11:10 - 11:30 |
Flora Hui |
NAM and functional recovery in human glaucoma |
| 11:30 - 11:50 |
Elena Veccino |
The whale´s RGCs: A long way to go |
| 11:50 - 12:00 |
Oliver Gramlich |
Targeting the cholesterol efflux transporter 1 ameliorates optic neuritis in EAE model |
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Lunch Break |
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Session III: Bioenergetics II |
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Moderators: Peter van Wijngaarden & David Krizaj |
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| 17:30 - 17:50 |
Tom McWilliams |
Landscapes of mitochondrial destruction in-vivo |
| 17:50 - 18:10 |
James Tribble |
Targeting Nmnats for neuroprotection in glaucoma |
| 18:10 - 18:30 |
Marcela Votruba |
Mitochondrial morphology drives bioenergetics defects in RGCs in mitochondrial optic neuropathies |
| 18:30 - 18:50 |
Jeff Goldberg |
Neural activity in retinal development and angiogenesis |
| 18:50 - 19:00 |
Lies De Groef |
Retinal phenotyping of mouse models of Alzheimer’s disease |
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Wednesday 11 December |
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Session IV: Disease Mechanisms, Therapeutics and Detection |
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Moderators: Franz Grus & Dietmar Fischer |
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| 8:30 - 8:50 |
Evan Reid |
Understanding cellular mechanisms of axonopathy in hereditary spastic paraplegia |
| 8:50 - 9:10 |
Dietmar Fischer |
New strategies to promote optic nerve regeneration |
| 9:10 - 9:30 |
Alice Pébay |
Modelling complex diseases with human pluripotent stem cells |
| 9:30 - 9:50 |
Peter van Wijngaarden |
Hyperspectral retinal imaging in Alzheimer’s disease |
| 9:50 - 10:00 |
Wolf Lagrèze |
Effect of high-dose intravenous erythropoietin in optic neuritis as a clinically isolated syndrome |
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Morning Tea |
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Session V: Retinal Response to Injury |
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Moderators: Bryan Jones & Jonathan Crowston |
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| 10:30 - 10:50 |
Bryan Jones |
Altered bipolar cell input to ganglion cells in retinal degeneration |
| 10:50 - 11:10 |
Romain Cartoni |
Using mitochondria to promote neuronal repair |
| 11:10 - 11:30 |
James Morgan |
Early changes in human glaucoma |
| 11:30 - 11:50 |
Mike Kapiloff |
cAMP compartmentation, mAKAPa signalosomes, and retinal ganglion cell neuroprotection |
| 11:50 - 12:00 |
Henrik Tonner |
Intravitreal injection of an anti-HMGB1 antibody attenuates neurodegeneration in a glaucoma animal model |
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Lunch Break |
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Session VI: Gene Therapy |
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Moderators: Keith Martin & Jeff Goldberg |
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| 17:30 - 17:50 |
Andy Osborne |
Gene therapy - protecting retinal ganglion cells via TrkB signalling |
| 17:50 - 18:10 |
Dominik Fischer |
Retinal gene therapy - lessons from treating RPE, rods and cones |
| 18:10 - 18:30 |
Veselina Petrova |
Protrudin enhances CNS axon regeneration through multiple novel pathways |
| 18:30 - 18:40 |
Discussion |
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Thursday 12 December |
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Session VII: Autophagy and -Omics |
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Moderators: Christian Behl & Katharina Bell |
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| 8:30 - 8:50 |
Christian Behl |
Autophagy response in chronic neuronal oxidative stress |
| 8:50 - 9:10 |
Katharina Bell |
Age related changes of rgc damage in an autophagy impaired model |
| 9:10 - 9:30 |
Moritz Helmstaedter |
Connectomics in brain diseases |
| 9:30 - 9:50 |
Julie Lefebvre |
Cellular and molecular strategies for retinal neuron wiring |
| 9:50 - 10:00 |
Carsten Schmelter |
Synthetic immunopeptides as new strategy in glaucoma therapy |
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Morning Tea |
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Session VIII: RGC Development |
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Moderators: Ed Levine |
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| 10:30 - 10:50 |
Ed Levine |
Using single-cell analysis to understand how Lhx2 controls inner retinal cell production |
| 10:50 - 11:10 |
Michel Cayouette |
New players in the transcriptional regulation of retinal ganglion cell fate specification |
| 11:10 - 11:30 |
Anna La Torre |
MicroRNAs in retinal ganglion cell production and survival |
| 11:30 - 11:50 |
Tom Reh |
Restoring the inner retina: endogenous or exogenous stem cell approaches |
| 11:50 - 12:00 |
Discussion |
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Lunch Break |
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Session IX: Regeneration, Repair and Plasticity |
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Moderators: James Morgan & Richard Eva |
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| 17:30 - 17:50 |
Richard Eva |
PI3 kinase delta and axonal regeneration |
| 17:50 - 18:10 |
Britta Eickholt |
Essential role of the actin cytoskeleton during astrogliosis and scar formation |
| 18:10 - 18:30 |
Ning Tian |
A dual neurotransmitter releasing bipolar cell participates in the homeostatic regulation of RGC synaptic connections |
| 18:30 - 18:40 |
Philipp Albrecht |
Protective effects of 4-Aminopyridine in experimental optic neuritis, optic nerve crush and multiple sclerosis |
| 18:40-19:00 |
Discussion and Wrap-Up of 2019 Meeting |
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