Optic Nerve Meeting 2019 10-12 December
Obergurgl, Austria
AGENDA
Tuesday 10 December | ||
8:30 - 8:40 | Jonathan Crowston, Franz Grus & Keith Martin | Welcome and Introduction |
Session I: Astrocytes | ||
Moderators: Andras Lakatos & Elena Vecino | ||
8:40 - 8:50 | Andras Lakatos | Is there a point in studying interspecies differences in astrocyte biology and pathology? |
8:50 - 9:10 | Lea Wenger | New tools for investigating human astrocyte diversity and reactivity |
9:10 - 9:30 | Colleen Limegrover | Astrocyte responses in human traumatic brain injury |
9:30 - 9:50 | David Krizaj | Neuronal and glial mechanotransduction: from retinal tension to dysfunction |
9:50 - 10:00 | Eirini Kokkali | When is a control eye not a control eye? Reactive microglia persist throughout the control contralateral visual pathway in experimental glaucoma |
Morning Tea | ||
Session II: Bioenergetics and Neuron-Glial Interactions | ||
Moderators: Bob Casson & Pete Williams | ||
10:30 - 10:50 | Pete Williams | From form to function: the effect of nicotinamide on retinal ganglion cell metabolism and mitochondria |
10:50 - 11:10 | Bob Casson | Gene therapy with neuroglobin in experimental glaucoma |
11:10 - 11:30 | Flora Hui | NAM and functional recovery in human glaucoma |
11:30 - 11:50 | Elena Veccino | The whale´s RGCs: A long way to go |
11:50 - 12:00 | Oliver Gramlich | Targeting the cholesterol efflux transporter 1 ameliorates optic neuritis in EAE model |
Lunch Break | ||
Session III: Bioenergetics II | ||
Moderators: Peter van Wijngaarden & David Krizaj | ||
17:30 - 17:50 | Tom McWilliams | Landscapes of mitochondrial destruction in-vivo |
17:50 - 18:10 | James Tribble | Targeting Nmnats for neuroprotection in glaucoma |
18:10 - 18:30 | Marcela Votruba | Mitochondrial morphology drives bioenergetics defects in RGCs in mitochondrial optic neuropathies |
18:30 - 18:50 | Jeff Goldberg | Neural activity in retinal development and angiogenesis |
18:50 - 19:00 | Lies De Groef | Retinal phenotyping of mouse models of Alzheimer’s disease |
Wednesday 11 December | ||
Session IV: Disease Mechanisms, Therapeutics and Detection | ||
Moderators: Franz Grus & Dietmar Fischer | ||
8:30 - 8:50 | Evan Reid | Understanding cellular mechanisms of axonopathy in hereditary spastic paraplegia |
8:50 - 9:10 | Dietmar Fischer | New strategies to promote optic nerve regeneration |
9:10 - 9:30 | Alice Pébay | Modelling complex diseases with human pluripotent stem cells |
9:30 - 9:50 | Peter van Wijngaarden | Hyperspectral retinal imaging in Alzheimer’s disease |
9:50 - 10:00 | Wolf Lagrèze | Effect of high-dose intravenous erythropoietin in optic neuritis as a clinically isolated syndrome |
Morning Tea | ||
Session V: Retinal Response to Injury | ||
Moderators: Bryan Jones & Jonathan Crowston | ||
10:30 - 10:50 | Bryan Jones | Altered bipolar cell input to ganglion cells in retinal degeneration |
10:50 - 11:10 | Romain Cartoni | Using mitochondria to promote neuronal repair |
11:10 - 11:30 | James Morgan | Early changes in human glaucoma |
11:30 - 11:50 | Mike Kapiloff | cAMP compartmentation, mAKAPa signalosomes, and retinal ganglion cell neuroprotection |
11:50 - 12:00 | Henrik Tonner | Intravitreal injection of an anti-HMGB1 antibody attenuates neurodegeneration in a glaucoma animal model |
Lunch Break | ||
Session VI: Gene Therapy | ||
Moderators: Keith Martin & Jeff Goldberg | ||
17:30 - 17:50 | Andy Osborne | Gene therapy - protecting retinal ganglion cells via TrkB signalling |
17:50 - 18:10 | Dominik Fischer | Retinal gene therapy - lessons from treating RPE, rods and cones |
18:10 - 18:30 | Veselina Petrova | Protrudin enhances CNS axon regeneration through multiple novel pathways |
18:30 - 18:40 | Discussion | |
Thursday 12 December | ||
Session VII: Autophagy and -Omics | ||
Moderators: Christian Behl & Katharina Bell | ||
8:30 - 8:50 | Christian Behl | Autophagy response in chronic neuronal oxidative stress |
8:50 - 9:10 | Katharina Bell | Age related changes of rgc damage in an autophagy impaired model |
9:10 - 9:30 | Moritz Helmstaedter | Connectomics in brain diseases |
9:30 - 9:50 | Julie Lefebvre | Cellular and molecular strategies for retinal neuron wiring |
9:50 - 10:00 | Carsten Schmelter | Synthetic immunopeptides as new strategy in glaucoma therapy |
Morning Tea | ||
Session VIII: RGC Development | ||
Moderators: Ed Levine | ||
10:30 - 10:50 | Ed Levine | Using single-cell analysis to understand how Lhx2 controls inner retinal cell production |
10:50 - 11:10 | Michel Cayouette | New players in the transcriptional regulation of retinal ganglion cell fate specification |
11:10 - 11:30 | Anna La Torre | MicroRNAs in retinal ganglion cell production and survival |
11:30 - 11:50 | Tom Reh | Restoring the inner retina: endogenous or exogenous stem cell approaches |
11:50 - 12:00 | Discussion | |
Lunch Break | ||
Session IX: Regeneration, Repair and Plasticity | ||
Moderators: James Morgan & Richard Eva | ||
17:30 - 17:50 | Richard Eva | PI3 kinase delta and axonal regeneration |
17:50 - 18:10 | Britta Eickholt | Essential role of the actin cytoskeleton during astrogliosis and scar formation |
18:10 - 18:30 | Ning Tian | A dual neurotransmitter releasing bipolar cell participates in the homeostatic regulation of RGC synaptic connections |
18:30 - 18:40 | Philipp Albrecht | Protective effects of 4-Aminopyridine in experimental optic neuritis, optic nerve crush and multiple sclerosis |
18:40-19:00 | Discussion and Wrap-Up of 2019 Meeting | |